Sakai clinic 62 has been selected as one of the top regenerative medicine service providers in the Asia-Pacific region for 2025.
This selection was based on evaluations conducted by a panel of experts, including the editorial board of Health Care Business Review magazine and industry professionals.
A cover story featuring our clinic’s treatments and the director has been published in Health Care Business Review APAC magazine.
The content of the article is also available on our website.
Health Care Business Review
This page provides detailed information about our clinic’s initiatives.
1. Cover Story
Medical Corporation Sakai Clinic 62 helps patients regain their natural beauty through cosmetic medicine.
My aim is to “move my patients”.
I originally specialized in orthodontics, and have performed more than 300 cases of frenectomy since I started my own practice. In addition to this surgery, I have been committed to safe and reliable treatment with no accidents since I started my practice.
I have been also well-versed in regenerative medicine and has obtained numerous patents.
One of the most unique is fibroblast regeneration therapy. Normally, fibroblasts are collected from behind the ear, so a scar will remain. This means that the wound will need to be stitched and the stitches removed after collection.
However, at Sakai Clinic 62, fibroblasts are collected from the oral mucosa or the gums. This means that there is no need to scar the body or remove stitches.
In addition, the fibroblast cells taken from the oral mucosa have a higher activation rate than those taken from the skin, so you can expect a high level of effectiveness.
In other words, you can expect a higher level of improvement for skin aging, such as sagging and wrinkles, than with general fibroblast regeneration therapy.
In addition, because we also perform regenerative medicine in the dental field, after culturing the fibroblast cells that have been taken, they can be used not only for skin regeneration but also for gum regeneration.
The following are the treatment menus for regenerative medicine at Sakai Clinic 62.
Sakai Clinic 62's original telomere injection (macrophage activation injection)
This is a safe and reliable injection that is a “patented in Japan” original Sakai Clinic formulation of a macrophage activation injection, and it is effective for preventing telomere deterioration, maintaining health and rejuvenation.
Highly activated NK cell therapy
In highly activated NK cell therapy, the patient’s blood is collected, and using the latest cultivation technology, the NK cells are multiplied and activated, and then returned to the patient’s body after being multiplied by several hundred to several thousand times in a sterile state over a period of about three weeks. After that, over a period of about three weeks, the blood that was taken is cultured and activated by skilled culturing technicians by hand in a specialized culturing facility that is kept in a sterile state. The actual treatment also only involves “blood collection” to collect the NK cells and “intravenous drip” to return the proliferated and activated NK cells to the body again.
Autologous adipose-derived stem cell therapy (intravenous drip only)
A small amount of your own stem cells are collected and cultured under strict control. They are then administered via an IV drip and gather at the site that needs to be repaired, repairing and regenerating the tissue. *Up to 100 million cells can be administered per session. Effective for diabetes. *At our clinic, you can choose between safe fetal bovine serum or a version that does not contain animal-derived ingredients. The price is double for the version that does not contain animal-derived ingredients.
Autologous fat-derived stem cell therapy (skin, face, neck, gums, alveolar bone, hair)
A small amount of your own stem cells is extracted and cultured under strict control. This is then administered via intravenous drip or local injection, and the cells gather in the areas that need to be repaired, repairing and regenerating the tissue. This is effective for the face, neck, skin, whole body, mouth and hair. With this treatment, up to 1.6 billion cells can be administered in a single dose.
In addition, Sakai Clinic 62 also offers
the latest anti-aging treatments such as Volnewmer, Inmode, and Morpheus8.
■ Inmode Mini
Elsewhere, I am also involved in the supervision of “nahls pure”, an anti-aging lotion containing a pure Japanese human stem cell culture extract. nahls pure is a high-quality, high-function lotion containing the “nahlsgen” ingredient invented at Kyoto University in Japan, and is recommended for anti-aging from your 30s onwards.
■ Nahls Pure
The Sakai Clinic 62 also employs plastic surgeons and cosmetic dermatologists, and is able to provide treatments in the field of cosmetic surgery, such as thread lifts and double eyelid surgery.
The doctors and staff all work together as a team to provide the best possible support for our patients.
2. Cooperation
I spend around 60 minutes carefully
counseling all of our patients. I confirm their requests and needs, and then
propose the most suitable treatment.
Once the treatment has been decided, we
assign doctors and staff from our clinic who are experts in their respective
fields.
Orthodontics, cosmetic dentistry,
regenerative medicine and immunotherapy are areas where I can make use of my
expertise, so I will be in charge of these treatments.
On the other hand, if it is a thread lift
or double eyelid surgery, the treatment will be carried out by a doctor with
whom we have a partnership.
In all cases, I believe it is important
that the patient and I share the goal through the counseling process first.
We also have a system in place that allows
us to share the patient’s wishes and goals with the staff involved in the
procedure, so that we can function as a team.
3. Telomere Infusion
Telomere infusion and injection is a very unique treatment for which our clinic has obtained a patent.
There is an enzyme called “telomerase” that can slow down the shortening of telomeres and even lengthen them.
Telomere infusions and injections activate telomerase, restoring the self-replicating ability of aged stem cells and damaged DNA, and are effective for rejuvenation.
In addition, by also adding an ingredient that activates macrophages in immunotherapy, we have created a telomere infusion and injection that activates macrophages as well as telomeres.
The functions and mechanisms of such telomere infusions and injections are due to the patented ingredients used in their formulation.
First, we will explain the function of macrophages, which is important for understanding telomere infusions.
Macrophages are a type of white blood cell that migrates to various organs such as the brain and liver, and has the ability to engulf foreign substances.
Macrophages protect human health by attacking foreign substances that have invaded the body and degenerative substances produced within the body, with their phagocytosis being activated by cytokines, which are small proteins secreted by T cells.
However, on the other hand, there are cases where macrophages become excessively activated and excessive inflammatory reactions occur due to factors such as excessive protein expression. As a result, it has been pointed out that this can cause various diseases such as arthritis and allergies.
The Telomere Infusion/Injection was developed with a focus on the effects of macrophage activation. In addition, the ingredients are blended in a balanced way to prevent excessive inflammatory reactions in macrophages.
Furthermore, while conducting research into the use of mitochondrial activation to improve infertility, we discovered a combination of ingredients that is effective in treating diseases caused by abnormal immune responses, such as terminal cancer, atopy, allergies, and the aftereffects of viral infections, as well as brain function, etc.
specifically, by combining chondroitin sulfate, unsaturated fatty acids, B vitamins, and nicotinamide mononucleotide in the optimal balance, we have adjusted the formula to normalize immune system abnormalities.
In other words, the various ingredients contained in the telomere drip and injection interact with each other to control cell characteristics while suppressing excessive activation of specific cells.
In addition to chondroitin sulfate and unsaturated fatty acids, the combination of vitamin B and nicotinamide mononucleotide (NMN) has been found to not only normalize immune system abnormalities, but also improve brain function and other aspects of the body.
Furthermore, nicotinamide mononucleotide (NMN) is expected to have a significant effect on diseases caused by abnormal immune system function by activating the sirtuin gene.
In addition, it has been found that it has physiological effects such as promoting the synthesis of hemoglobin and the biosynthesis of proteins and nucleic acids, while also having anti-arteriosclerosis, antioxidant and anti-inflammatory effects.
Furthermore, it has been found that it can control cell proliferation, cell differentiation and the induction of cell death, as well as
controlling the excessive activity of cells that may cause immune abnormalities, such as cells related to biological defense and inflammation.
In this way, the telomere drip/injection has been patented for its balanced combination of drugs that can be expected to have only the benefits of macrophages.
4. Culture medium
We use fetal bovine serum (FBS: Fetal Bovine Serum) culture medium and non-animal-derived culture medium.
We use fetal bovine serum (FBS) that complies with the “Standards for Biological Materials” (Ministry of Health, Labor and Welfare Notification No. 210 of 2003).
Specifically, the following points are important.
l We only use FBS from Europe.
l It is manufactured in a factory that complies with SO9001, and thequality of each manufacturing process can be traced back to the raw materials.
l The following quality inspections are carried out on all lots before shipment.
・Sterility test
・Endotoxin test
・Mycoplasma negative test
・Virus test
・BovineViralDiarrhoea
・Cytopathogenicagentsg.g.InfectiousBovineRhinotracheitis
・ParainfluenzaType3
It is possible to obtain a data sheet like
the one on the right for each lot.
It is also possible to choose a non-animal
medium.
The price will be twice as much, but the
risk of allergies etc. will be even lower.
5. Invisa Beauty
Invisa Beauty is a new three-dimensional
orthodontic treatment method that incorporates my own unique contouring and
skeletal correction into Invisalign mouthpiece orthodontics.
It is an orthodontic method that I created
as the culmination of my many years of experience as an orthodontist and my
extensive knowledge of beauty.
The name is a combination of “Invisalign”
and “beauty”.
Invisalign can be used to treat a wide
range of conditions compared to other types of mouthpiece orthodontics, but it
cannot be used to adjust the face in three dimensions.
Invisa Beauty is a treatment that overcomes
this weakness.
It is possible to adjust the face in three
dimensions, which was not possible with previous mouthpiece orthodontics, and
to propose a beauty that suits each individual.
We provide total beauty by adjusting the
shape, size, color and gums of each tooth to match the natural beauty of each
patient’s face.
While providing thorough counseling, we
design a finish that matches each patient’s occupation, image and wishes.
This design ability is my original and the
essence of Invisa Beauty.
We design the outline of the teeth so that
they look well-balanced when viewed from the front, from the side, or from
below. We pay attention to the amount and angle of each tooth that can be seen
from the lips, so you can experience both functionality and aesthetics.
For example, if the outline of the teeth
becomes narrower overall, it will make the mouth more prone to wrinkles.
By widening and straightening the outline
of the teeth, the wrinkles will become less noticeable and sagging will be
eliminated.
In other words, we not only straighten the
teeth, but also balance the skin and muscles, and correct the entire face.
Contouring is achieved by correcting not
only the teeth, but also the skeletal structure. For those who are concerned
about their jaw being too prominent, for example, correcting the jawline can
help to create a more defined E-line, and in some cases, the nose may appear to
be higher. By widening the teeth, the cheekbones become higher, and a
three-dimensional effect is created on the face.
In addition to this, by performing cosmetic
procedures such as photofacial, hyaluronic acid injections, etc., Invisa Beauty
not only corrects malocclusion, but also helps to resolve each patient’s
individual concerns and make their dreams come true.
6. Case Studies
Here we will introduce three case studies.
In all cases, we did not simply perform
treatment, but instead provided counseling on how to maintain natural beauty,
and proposed the treatment we thought would be most suitable.
The first is a case study of Invisa Beauty.
While undergoing Invisalign treatment at
another clinic (4 teeth had already been extracted), the patient was concerned
about the fact that her cheeks had started to look gaunt and her face had
become long and narrow, and she came to our clinic in the hope of improving the
situation.
As she was still in the middle of
orthodontic treatment, the back teeth were not aligned and she had a habit of
pushing her tongue forward, so her upper and lower front teeth were protruding
slightly.
By the time her orthodontic treatment at
our clinic was complete, the gauntness of her cheeks had disappeared, giving
her a more energetic and youthful appearance, and her jaw had shortened, giving
her a smaller face.
Her profile also became more beautiful,
with a higher nose and a more beautiful E-line.
The patient was very satisfied with the
results of her treatment at our clinic.
The second case is a scar revision.
This patient was injured in an accident,
and her skin and lips were torn open so badly that she could not even open her mouth. In addition, she was worried about the scar on her eyebrow, and her husband had also pointed out that her face had become unnatural.
She came to our clinic to discuss her concerns.
We therefore proposed a treatment using bone marrow stem cell supernatant fluid, rather than a plastic surgery
approach, in order to restore natural beauty after the procedure, rather than simply repairing the scars.
The patient accepted this treatment and underwent three procedures.
As a result, the scars on the inside and outside of the mouth became less noticeable. In addition, the scars on the eyebrows also became almost unnoticeable, and the patient was very pleased.
The third case is a treatment for wrinkles around the knees using autologous fat grafting.
The patient was a 60-year-old woman who had
developed wrinkles around her knees as she aged.
She was embarrassed to show her knees and
was no longer able to enjoy fashion as she wished, for example, by wearing
skirts.
So, in order to improve the wrinkles and
restore her natural beauty, she decided to have a fat grafting procedure. As a
result, the wrinkles became less noticeable and she was able to enjoy fashion
more freely, such as being able to wear miniskirts. Furthermore, she also had
fat grafting procedures on her breasts and hands in order to rejuvenate
herself.
Now, she no longer has any complexes about
aging and is enjoying life to the fullest.
At Sakai Clinic 62, we provide treatment with the aim of helping our patients regain their natural beauty and live their lives with confidence after the procedure.
The prices for beauty treatments on this page are for residents of Japan.
Prices for foreign patients are separate.
Please contact the clinic for details.
